A new study reveals a possible protein misfolding mechanism that may resolve a long-standing mystery of why certain proteins ...

Proteins are long molecules that must fold into complex three-dimensional structures to perform their cellular functions.

To maintain homeostasis, intestinal epithelial cells (IECs) must efficiently manage protein production and secretion, a process tightly controlled by the unfolded protein response (UPR).

Subscribe for FREE “For most proteins, we model the folding process as if there are two states, folded or unfolded,” said Yang Jiang, assistant research professor of chemistry in the Eberly College of ...

To maintain homeostasis, intestinal epithelial cells (IECs) must efficiently manage protein production and secretion, a process tightly controlled by the unfolded protein response (UPR).

successfully visualized how the SecYEG-SecA complex helps mediate the translocation of unfolded proteins across the bacterial membrane at a molecular level. Real-time dynamics of protein ...