Cells from the telomerase knockout mouse immortalize with ... of this difference between mice and men and its relationship to cancer. The evidence supporting the relevance of replicative ...

Unicellular organisms, human cells and mice have provided ... has been aided by genetically defined cancer-prone mice that lack telomerase activity. These mouse models have provided insights ...

In contrast to human somatic cells that are telomerase negative, telomerase activity is typically ... 8 The observed association between shorter telomeres and increased risk of cancer, cardiovascular ...

The laboratory is using or has plans to use many cutting-edge technological developments in cancer and aging genetics and translational research such as RRBS-seq and Single-cell epigenomics. Studies ...

Those that are too long predispose to cancer, and those that are too short lose their protective ability, resulting in ...

The European Commission has approved Rytelo treatment in transfusion-dependent anemia due to very low–, low– or ...

Researchers say they are exploring therapeutic options to block fatty acid accumulation and immunosuppressive signals between ...

Telomeres, along with the enzyme telomerase, play a fundamental role in the survival of cancer cells and their resistance to current therapies. The modified nucleotide 6-thio-2’-deoxyguanosine ...

Telomeres, along with the enzyme telomerase, play a fundamental role in the survival of cancer cells and their resistance to current therapies. The modified nucleotide 6-thio-2’-deoxyguanosine ...