It is widely understood that sepsis occurs as a result of the complex ... Each TLR can be activated by a variety of molecules; however, TLR4 mainly recognizes LPS, TLR2 mainly recognizes MDP ...

In addition, Poltorak et al. (1998) demonstrated that mice with a defective version of TLR4 are completely resistant to LPS-induced sepsis. This established that TLR4 is the receptor for LPS ...

Sepsis is a common and serious complication in intensive care unit patients. An important factor in optimizing survival rates in septic patients is the ability to start treatment early in the ...