[19] Another molecule that interferes with TLR4 signaling is TAK 242. It was evaluated in a randomized study of 274 patients with severe sepsis and shock or respiratory failure. The trial aimed to ...

In addition, Poltorak et al. (1998) demonstrated that mice with a defective version of TLR4 are completely resistant to LPS-induced sepsis. This established that TLR4 is the receptor for LPS ...

Accurate and early diagnosis of sepsis may help reduce unnecessary antibiotic therapy and investigative tests and by enabling rapid treatment can improve outcomes. The systemic inflammatory ...