Huntington's disease is a rare genetic, autosomal dominant, neurodegenerative disease, caused by CAG repeat expansions in the HTT gene, that is polymorphic on the healthy allele and contains more than ...

They include the dysregulation of the expression of thousands of genes in the striatal neurons and an accumulation of clumps of mutant Huntingtin protein (called aggregates), which are a hallmark ...

Distinct populations of striatal neurons were found to represent different parts of the reward distribution, with D1 neurons encoding the upper range consisting of optimistic predictions ...

Although most cells showed modest somatic expansions, the longest expansions — some of which exceeded 800 repeats — were found exclusively in medium spiny neurons (also called striatal ...

Knocking it down with an antisense oligonucleotide blocked CAG expansion in HD neurons. The ASO also took down MSH3 in the brains of human MSH3 knock-in mice. In stem-cell-derived striatal neurons ...

He and his team used RNA sequencing to analyze the mice’s striatal spiny neurons, which are involved in producing the behavior-reinforcing neurotransmitter dopamine both before and after exercise, and ...