To overcome the inherent challenge of translation termination interference caused by stop codon reprogramming in mammalian cells, researchers from Peking University led by Chen Peng from College ...

It basically put a stop sign, called a stop codon, toward the beginning of the KEAP1 gene. Stop codons generally signal where a gene ends, so having one at the start would "break" the gene.

More information: Jiangle Liu et al, RNA codon expansion via programmable pseudouridine editing and decoding, Nature (2025). DOI: 10.1038/s41586-025-09165-x ...

Peking University, June 27, 2025: To overcome the inherent challenge of translation termination interference caused by stop codon reprogramming in mammalian cells, researchers from Peking ...