The hedgehog (Hh) signaling pathway regulates the differentiation and growth of numerous cell types, including chondrocytes, and thus is essential for normal skeletal development. Pharmacological ...

The key to understanding their origin is found in embryonic development and a molecular signaling pathway called Sonic Hedgehog (Shh). In this study, the team temporarily recreated a more ...

studies the role of molecular signaling pathways (communication systems that transmit messages within and between cells), such as the Sonic Hedgehog (Shh) pathway, in the embryonic development of ...

Inhibiting the sonic hedgehog (Shh) pathway strongly perturbs ... injections of sonidegib to pharmacologically inhibit Shh pathway signaling during feather development at embryonic day 9, which ...

Several components of the hedgehog (Hh) pathway are crucial to basal cell carcinoma (BCC) tumorigenesis. Primary cilia have emerged as key organelles in Hh signal transduction in mammalian systems ...

Tweaking the Sonic Hedgehog gene can transform different aspects of development in chickens. For instance, transient over-expression of the gene can permanently turn feet scales into feathers.