Chickens treated to inhibit the sonic hedgehog (Shh) pathway during development grow feathers that resemble ancient ...

The hedgehog (Hh) signaling pathway regulates the differentiation and growth of numerous cell types, including chondrocytes, and thus is essential for normal skeletal development. Pharmacological ...

The key to understanding their origin is found in embryonic development and a molecular signaling pathway called Sonic Hedgehog (Shh). In this study, the team temporarily recreated a more ...

Inhibiting the sonic hedgehog (Shh) pathway strongly perturbs ... injections of sonidegib to pharmacologically inhibit Shh pathway signaling during feather development at embryonic day 9, which ...

Several components of the hedgehog (Hh) pathway are crucial to basal cell carcinoma (BCC) tumorigenesis. Primary cilia have emerged as key organelles in Hh signal transduction in mammalian systems ...

Glypican members of the heparan sulphate proteoglycan family regulate several developmental signalling pathways, such as those involving Hedgehog, Wnt, BMP and FGF. Two studies reveal opposite ...