Given the amino-acid sequence or 3D structure of a protein, how much can we predict about its function using just a desktop computer? The recent explosive growth in the volume of sequence data and ...

This Opinion article describes the newly discovered conserved immunological and structural features of the sequence-variable regions of HIV-1 gp120, which the authors suggest warrant the ...

It integrates sequence, structure, and function to generate proteins following complex prompts. Notably, ESM3 generated a new fluorescent protein, esmGFP, which is 58% different from any known ...

This vast chemical and structural space has created significant challenges for rational design of new structures and functions as the underlying molecular scale driving forces that give rise to ...

Improving the ability to predict protein function can potentially facilitate research in the fields of drug discovery and precision medicine. Technically, the properties of proteins are directly or ...