However, high-resolution structural investigations of rhodopsin have been less successful — until now. The structure of rhodopsin clearly shows the seven membrane spanning helices as well as the ...

Rhodopsin is the only G protein-coupled receptor for which a structure has been determined by x-ray crystallography. While the structure of rhodopsin has had an enormous impact on our understanding of ...

Previous efforts on in silico screening for GPCR ligands used receptor-homology models based on the inactive rhodopsin structure. The newly determined crystal structures of β2AR provide a better ...

The quest to identify effective treatments for RP has driven scientists to explore small molecules that stabilize rhodopsin’s structure. Using virtual screening methods, researchers analyzed ...

This study makes the fundamental discovery of the first natural animal rhodopsin that uses a chloride ion instead of an amino acid side chain as a counterion. Using a combination of biochemical and ...