The quest to identify effective treatments for RP has driven scientists to explore small molecules that stabilize rhodopsin’s ...

The crystal structure ... of complex chemical libraries. Previous efforts on in silico screening for GPCR ligands used receptor-homology models based on the inactive rhodopsin structure.

However, high-resolution structural investigations of rhodopsin have been less successful — until now. The structure of rhodopsin clearly shows the seven membrane spanning helices as well as the ...