Transmembrane signaling systems include membrane ... The discovery of receptor tyrosine kinases: Targets for cancer therapy. Nature Reviews Cancer 4, 361–370 (2004) doi:10.1038/nrc1360.

The molecular basis of phospho-tyrosyl-regulation of Src-family and Syk-family protein tyrosine kinases in signaling pathways ... of Syk tyrosine kinase binding to membrane immune receptors and other ...

For instance, neurotransmitters are a class of short-range signaling molecules ... intracellular signals for every one receptor that is bound. Protein kinases such as PKA and PKC catalyze the ...

Sorafenib is an oral multikinase inhibitor that inhibits tumor growth and proliferation by interfering with several receptor tyrosine kinases involved in the pathogenesis and perpetuation of ...

Nuvalent Inc. has identified proto-oncogene tyrosine-protein kinase ROS (ROS1; MCF3) and/or ALK tyrosine kinase receptor inhibitors reported to be useful for the treatment of cancer.

Additionally, bsAbs targeting tumor growth factors or receptor tyrosine kinases offer solutions for overcoming drug ... engagement of two antigens to induce specific downstream signaling. For example, ...

Hsp90 is a chaperone required for maintaining the proper conformation of several important signaling proteins, including transmembrane tyrosine kinases and steroid receptors. The laboratory is ...