They do so because when an RTK becomes activated, the result is phosphorylation of specific tyrosines on the cytoplasmic tail, the intracellular portion of the receptor. This phosphorylation leads ...

RTK, receptor tyrosine kinase; TSC1/2, tuberous sclerosis complex 1/2. The PIK3CA gene, which encodes the p110α subunit of phosphoinositide 3-kinase (PI3K), is among the most frequently mutated ...

“So much of drug development is ‘me-too’, with multiple companies targeting the latest activating mutation in a particular RTK [receptor tyrosine kinase] target,” Hembrough added.

I study and characterize the response to KRAS G12C, SOS1 and SHP2 inhibitors alone or in combination with receptor tyrosine kinase (RTK) or MEK inhibitors in different tumor types to determine the ...