Among anti-nuclear antibodies, anti-Sm and anti-RNP antibodies are of the utmost importance in clinical practice. Anti-Sm antibodies are directed against 7 proteins (B/B', D1, D2, D3, E ...

For this purpose, a doctor may order anti-dsDNA, anti-Sm, Sjögren's antigens (SSA, SSB), Scl-70 antibodies, anti-centromere, anti-histone, and anti-RNP. The ANA blood test can seem complicated.

Class R INH-ODNs also inhibited the secretion of anti-dsDNA and anti-Sm/RNP antibodies more effectively than class B INH-ODNs. The increased potency of class R INH-ODNs for autoreactive B cells ...