The front sight is interchangeable and has a Red-Ramp face on the visible side, which allows the revolver to be zeroed with both full power .357 Mag. loads or softer .38 Spl. loads.

Since the 2020 re-introduction of the Python revolver, Colt purists clamored for the return of the blued models, and this year, Colt obliged with its blued 4.25" Python revolver.