Guanine is also a component of important biomolecules such as GTP (guanosine triphosphate), which is involved in cellular signaling and protein synthesis. In addition to their role in nucleic acids, ...

Hyperuricemia (HU), characterized by elevated uric acid (UA) levels in the blood, is a global health concern associated with various conditions, including cardiovascular diseases, gout, hypertension, ...

Purine nucleotides are essential for cell growth and function as they serve as nucleic acid building blocks, signaling molecules, and energy carriers. Treatments that inhibit their synthesis offer a ...

They soon discovered, from observing the role of purines in nucleic acid metabolism, that bacterial cells require certain purines to make DNA. Hitchings hypothesized that by preventing those purines ...

Forty % of sudden infant death syndrome (SIDS) babies have higher hypoxanthine (Hx) cone, in their vitreous humor than respiratory distress syndrome (RDS) babies (unpublished data). To investigate ...

Hyperuricemia (HU) is a metabolic disorder characterized by elevated uric acid (UA) levels in the bloodstream, commonly diagnosed when UA levels exceed 420 µmol/L (7 mg/dL) in men and 350 µmol/L (6 mg ...