Elevated levels of NE, proteinase 3 (PR3), and cathepsin G (CatG) can overwhelm the natural inhibitors, altering the airway microenvironment and increasing the risk of infection. Neutrophils play ...

8 In neutrophils, LAMP-2 is located on the membranes of intracellular vesicles that contain myeloperoxidase and proteinase 3, and is also abundant on the surface of endothelial cells. LAMP-2 has ...

Journal of Neuroinflammation. (2017) Neutrophil Elastase-Induced Inflammation and Pain in Mouse Knee Joints via Activation of Proteinase Activated Receptor-2. MM Muley, AR Reid, B Botz, Z Helyes & JJ ...