They work by mimicking the effects of a natural hormone called prostacyclin. Their mechanism of action includes stopping platelets from forming clots in your blood vessels and causing vasodilation ...

By leaving cyclo-oxygenase 1 (COX1)-mediated platelet aggregation and gastric ... of COX2-selective inhibitors might be caused by a prostacyclin and thromboxane imbalance, multiple opposing ...

"The prostacyclin drug class sells over $3.3 billion ... It exerts its pharmacological action through vasodilation and platelet aggregation and by inhibiting smooth muscle proliferation.