The pro-apoptotic BCL-2 proteins are functionally ... also known as PUMA), function in distinct cellular stress pathways and signal that a stress has occurred through interactions with other ...

BAD is a pro-apoptotic member of the Bcl-2 family that is tightly regulated by survival factors. Several major signalling pathways influence cell death through their direct effects on the ...

We have shown that tumors with HER2 amplification or PI3K mutation are selectively dependent for growth on the PI3K pathway and are sensitive to specific inhibitors of PI3K or AKT. Inhibition of PI3K ...