In other words, PrPSc converts PrPC into PrPSc. Prions do not contain a nucleic acid genome J.S. Griffith first proposed the protein-only theory in 1967 to explain how prions could replicate if ...

Prions, the causative agents of transmissible spongiform encephalopathies, appear to consist entirely of PrP Sc, an orderly aggregated, β sheet–rich isoform of a ubiquitous membrane protein ...

Mark Purdey was an organic farmer turned self-taught scientist who developed the theory that organophosphate pesticides had caused cow prion proteins to go rogue, causing BSE. Over the years ...