Before the discovery of agents that specifically inhibited osteoclastic bone resorption, there was no effective treatment for Paget's disease. This situation changed with the development for ...

Dear Reader: The full name of the condition you have been diagnosed with is Paget’s disease of bone. Also known as osteitis deformans, it is a chronic bone disorder. When someone has Paget’s ...

Intensive bisphosphonate treatment does not confer a clinical advantage over treatment of symptoms alone in patients with Paget disease of bone. Findings from a UK study reveal that maintenance of ...

X denotes truncating mutation. PEST2 domain 345–377; UBA domain 387–436. *Two different mutations reported to cause this truncation. ‡ Results from splice site mutations (intron 7 ...