The phosphatidylinositol-3-kinase (PI3K) pathway plays a crucial role in cell growth and survival and is activated in various cancers. Multiple components of the pathway are frequently targeted by ...

Melanoma is the deadliest form of skin cancer, and cases are rising. Since 2000, diagnoses in the U.S. have increased from 18 ...

Dr. Kevin Kalinsky discusses the role of targeted therapy and clinical decision-making in managing estrogen-driven, ...

Researchers sought to evaluate differences in ctDNA profiles, use of targeted treatments, and overall survival between Black and White patients with metastatic breast cancer.

We have shown that tumors with HER2 amplification or PI3K mutation are selectively dependent for growth on the PI3K pathway and are sensitive to specific inhibitors of PI3K or AKT. Inhibition of PI3K ...

Daily aspirin use after standard adjuvant therapy did not improve DFS for patients with colorectal cancer, according to ...

Phagocytosis is a fundamental mechanism used by the body to resist pathogens and restore physiological homeostasis. Herein, to identify small molecules with anti-inflammatory properties via ...

Patients with treated, PI3K-mutated early CRC had a 50-60% lower ... patients with tumors harboring mutations in the PI3 kinase pathway," said Martling. "This is the first trial to show that ...

Torqur AG, an innovative clinical-stage biotechnology company dedicated to advancing treatments for oncology and dermatology, ...

Celcuity's gedatolisib, a dual PI3K/mTOR inhibitor, shows promise in Phase 3 breast cancer trials. Click here to read an analysis of CELC stock now.

1 Primarily driven by an overactive PI3K pathway, early research suggests targeted therapy could hold promise for many patients. The study evaluates the safety and efficacy of topical gel ...