they all contained mutations. Once researchers redefined p53 as a tumor suppressor gene and generated nonmutated clones, they began piecing together the puzzle of its role in the cell. One group ...

When p53 is mutated, which occurs on average in one out of two cancers, these cells can continue to divide, accumulate more mutations, and ultimately ... A mechanosensitive nuclear checkpoint triggers ...

By analysing huge amounts of biological data, the use of machine learning accelerates the identification of critical control ...

p53 GENE MUTTION: Exons 5 and 6 of the p53 gene of five individuals were amplified and examined by Cleavase® Fragment Length Polymorphism (CFLP®) Analysis. The pattern marked "WT" is from an ...

This mutation weakened p53's ability to regulate certain genes but did not affect its ability to control calcium signaling, a process important for cell survival. The unexpected appearance of this ...

Of the many types of DNA damage that exist within the cell, probably the most dangerous ... key roles for these pathways in preventing mutations, chromosomal instability and cancer.

New research uncovers new insights into preventing chronic inflammation caused by aging-related zombie-like cells. In humans ...

Mutations in genes can cause cancer by accelerating cell division rates or inhibiting normal controls on the system, such as cell cycle arrest or programmed cell death. As a mass of cancerous ...