What about the rest of the cases of CHD? Noncoding DNA elements have long been thought to play a role in CHD, but few variants have been pinned down as causative. New work from the lab of ...

Most of these variants map to noncoding genomic regions ... Parking a giant CRISPR repressor on DNA is helpful for discovering causal variants, but it is not realistic in a biological sense. STING-seq ...

The researchers studied resistance variants found in the non-coding genome, which makes up 98% of DNA and does not contain genes. Previous attempts to identify resistance mechanisms to ...

Long noncoding RNAs (lncRNAs) are RNAs longer than 200 nucleotides that do not contain any open reading frames greater than 300 nucleotides (100 codons). The DNA sequences they’re transcribed from can ...

Our DNA is constantly under threat — from cell division errors to external factors like sunlight and smoking. Fortunately, ...

Swiss start-up Haya Therapeutics has formed a partnership with Eli Lilly – worth up to $1 billion – to look for new therapies for obesity in non-coding DNA. The biotech focuses on trawling the ...

The involvement of noncoding mRNAs in many regulatory processes ... that an "RNA world" may have preceded the evolution of DNA and proteins (Gilbert, 1986). Small interfering RNAs (siRNAs ...

Professor and HHMI Investigator Zachary Lippman and his colleagues have begun to uncover the ways in which fragments of non-coding DNA called cis-regulatory sequences dictate how, when ...

Using single-cell RNA sequencing, we mapped thousands of expression quantitative trait loci in yeast, including a variant in GPA1 that influences gene expression, cell-cycle occupancy, and mating ...