The Arizona Cardinals and San Francisco 49ers entered the season final both struggling, Arizona having lost five of six and the Niners six of seven. After some early success from the Niners ...

One early NFL power ranking for 2025 season has Arizona Cardinals on the cusp of being an NFL playoff team, but other ...

The Arizona Cardinals play their season finale at home in Week 18 against the San Francisco 49ers. Kickoff from State Farm Stadium is at 4:25 p.m. ET (2:25 p.m. Arizona time). The Cardinals have ...

Samuel has been a versatile piece for the 49ers since his arrival in 2019 as a second-round pick. In 81 games for San Francisco, he's tallied 5,935 scrimmage yards and has been a pivotal for the 49ers ...

For coach Jonathan Gannon and QB Kyler Murray, ending the season with a win will give Arizona a confidence boost heading into the offseason.

The 49ers granted Samuel and his agent permission to seek a trade once this latest request came a month ago, when Samuel, 29, ...

How do all 32 teams in the NFL stack up against each other going into the 2025 NFL offseason? Here's breaking down who's ...

The San Francisco 49ers are preparing for their Week 18 contest against the Arizona Cardinals on Sunday at State Farm Stadium in Glendale, Arizona. Several key players were absent from the second ...

James Conner will not play in the Arizona Cardinals’ season finale against the San Francisco 49ers. He was placed on injured reserve earlier this week, ending his season. Several other Cardinals ...

D.J. Reed's path to free agency started with the San Francisco 49ers, who drafted him in the fifth round of the 2018 NFL ...

TV: FOX. Radio: 98.7 FM. Last time they played: The 49ers made easy work of the Cardinals in a 45-29 win last December. That defeat is the most points the Cardinals have allowed in a game since 2016.

Here are three reasons why the 49ers will beat the Cardinals. The 49ers will have some trouble getting as motivated against the Cardinals as they were against the Lions. One game was against an ...