Microscopy image of a brain organoid showing neuron precursors (magenta) and deep-layer projection neurons (green), which are one of the cell types affected by autism risk gene mutations.

Using an unbiased approach, this important study discovered a role of Ezh2 in the differentiation of granule neuron precursors, the cell of origin for Shh group of medulloblastoma. Furthermore, the ...

The team focused on the role of one protein, enhancer of zeste homolog 2 (EZH2), because of its robust effect on controlling neuron maturation. When the researchers inhibited EZH2 in precursor cell ...