This approach will facilitate the creation of patient-specific kidney disease models and enhance efforts to identify nephron targeted drugs. Moreover, the cocktail is powerful enough to reprogram ...

Glomerular disease affects the Glomeruli and disrupts ... have about one million tiny filter units called nephrons. Each nephron has a glomerulus which work like strainers used in cooking.

Kidneys remove waste like urea and support red blood cell production (erythropoiesis). If unhealthy, they can cause high blood pressure, fluid retention, anemia, and heart disease. Proper nutrition is ...

Moreover, defects in nephron formation can predispose to Wilms tumour, the most frequent solid tumour in children. To understand the basis of human renal diseases, it is essential to consider how ...