Cobenfy’s late-stage flop is BMS’ second high-profile failure in as many weeks. The pharma announced last week that Camzyos ...

The pharmacotherapy of schizophrenia is currently dominated by atypical antipsychotics that primarily target dopaminergic signalling, the dysregulation of which has long been considered to have a ...

This is a change in market cap of about $6 billion. The muscarinic receptor is a type of acetylcholine receptor found in the ...

At present no definitive medical treatment exists for acute pancreatitis. [9,10] Pirenzepine has shown encouraging positive responses and a low incidence of adverse effects when used to treat ...

particularly the muscarinic M1 receptor, are important for mediating the effects of the cortical acetylcholine on attention (Burk & Robinson, 2010). Moreover, we have begun to elucidate the ...

The crown jewel of the acquisition was seen as emraclidine, an allosteric modulator that selectively targets the muscarinic acetylcholine 4 receptor subtype. It was seen as a potential next ...

Muscarinic receptors are involved with neurotransmission via acetylcholine and glutamate, and are hypothesised to be dysfunctional in schizophrenia. Most drugs developed to treat schizophrenia to ...

This valuable study shows that locomotion-related modulations in the mouse visual cortex are not uniform but primarily affect neurons in muscarinic receptor-negative patches, which receive projections ...

Anticholinergics prevent the increases in intracellular concentration of Ca++ which is caused by interaction of acetylcholine with the muscarinic receptors on bronchial smooth muscle. The ...

Homatropine is an anticholinergic that inhibits activity of the muscarinic acetylcholine receptor with less potency than atropine. Abuse potential (monitor). Life-threatening respiratory ...

New Delhi: The pharmaceutical major Cipla has got the go-ahead from the Subject Expert Committee (SEC) functional under the ...