Data from the Centers for Disease Control and Prevention show there were about 107,000 drug overdose deaths in the United States in 2023. Of those, about 75%, or 81,000, involved opioids.

and μ-opioid receptors. In this study, methadone and its analogues seemed to be more similar to the antimuscarinics ligand class, a prediction that was confirmed by cell-based functional assays ...