Profluent’s latest protein language model incorporates structural and functional context to decode the language of biology for fine-tuned protein design By Fay Lin, PhD August 5, 2024 ...

image: (a) Protein sequence-structure co-design with PocketGen; (b) Dual-layer graph Transformer encoder; (c) Pre-trained protein language model for sequence prediction and efficient fine-tuning.

Existing models allow us to decode the structures of molecules, but to make new medicines we need to be able to design them. Neo-1, for the first time, allows for this in a single unified model.” ...

Germany, have developed a new method that makes it possible for the first time to image the three-dimensional shape of proteins with a conventional microscope.