the number of mitochondrial genomes in each organelle—as part of a process called the mitochondrial unfolded protein response, or UPR mt. This process prompts the up-regulation of certain stress ...

which in turn activates the mitochondrial unfolded protein response (UPRmt) in the intestine. The findings are published in the Journal of Cell Biology. The researchers found that TMBIM-2 works in ...

The mitochondrial unfolded protein response (UPR mt) is a transcriptional program that is activated in cells experiencing mitochondrial stress and that helps to return to proteostasis and improve ...

Researchers at the Leibniz Institute on Aging—Fritz Lipmann Institute (FLI) in Jena have discovered a new function of the DNA ...

More information: Jordan Alyse Woytash et al, Mitochondrial unfolded protein response-dependent β-catenin signaling promotes neuroendocrine prostate cancer, Oncogene (2024). DOI: 10.1038/s41388 ...

The same biological processes that drive aging — such as energy loss — may also contribute to lung diseases like chronic ...