Similarly, a homoplasmic mutation in a mitochondrial genome-encoded ribosomal RNA, called RNR1, causes postlingual deafness (deafness that occurs after three years of age, when a child has already ...

Mitochondrial deoxyribonucleic acid (mtDNA) is essential for cellular energy production and overall cell function. Abnormalities in mtDNA are linked to various diseases and are also implicated in ...

Mitochondria produce some of the proteins they need themselves—with the help of special protein factories called mitoribosomes, which consist of RNA and proteins. Researchers in Göttingen have ...

Blum, B., Bakalara, N. & Simpson, L. A model for RNA editing in kinetoplastid mitochondria: RNA molecules transcribed from maxicircle DNA provide the edited information. Cell 60, 189–198 (1990).

Mitochondria possess two dynamic membranes that envelop a multi-copy genome essential for aerobic energy metabolism. Metazoan mitochondrial DNA is one of the most constrained and simplified genomes ...

To answer it, he and his colleagues first used various staining techniques to establish that both RNA-binding proteins and mRNA are colocalized with mitochondria in mouse, pig, cow, and human oocytes.

1 He and his team administered a short term high fat diet to mice before profiling sperm RNA expression changes and investigating offspring health. They found that the acute high fat diet induced ...

We have elected to study this process in the slime mold Physarum polycephalum (Pp), which carries out the widest range of RNA editing events yet described. These changes to mitochondrial RNAs involve ...

Selective reduction of OPA1 or MFN1 significantly rescued mitochondrial abnormalities, survival, and locomotor activity, whereas reduction of MFN2 had no effect. RNA sequencing of the pons/medulla ...

elegans mitochondrial factor WAH-1 promotes phosphatidylserine externalization in apoptotic cells through phospholipid scramblase SCRM-1 Xiaochen Wang1, Jin Wang2, Keiko Gengyo-Ando3, Lichuan Gu4, ...