The first thing you should do here is to close all programs that are using the Excel file you are attempting to open. Please ensure the .xls file is not opened in other workbooks, add-ins, or apps.

Open Microsoft Excel.; Go to “File > Options > Trust Center.” Now, click on the Trust Center Settings button.; Select Protected View from the left side.; Uncheck all the options on the right ...

File-security limits can curtail your ability to open or save Microsoft Excel files. Getty Malware can exploit your computer and your private information, but only if it manages to install itself.

When attempting to open a document that has triggered the use of the Protected View feature, like an Excel document, a message would pop up saying, "Microsoft Excel cannot open or save any more ...

Microsoft today released a pair of updates to address a bug introduced in Microsoft Office 2008 for Mac Service Pack 2 released last month that prevented users from opening some Office documents ...