Plaques all but vanish in response to some Aβ ... microglia in the non-immunized group, plaque-adjacent ones in immunized people were flush with transcripts encoding ApoE, TREM2, A2M, RAB13, FAM107A, ...

In Alzheimer’s Disease (AD), microglia receptors detect aggregated beta-amyloid (Aβ) and secrete signals to uptake the protein. Disease-state microglia also trigger inflammation in the CNS and display ...

Impact of CD2AP deficiency in microglia in Alzheimer’s disease (AD ... The Role of CD2AP in Amyloid-Beta Metabolism Aβ accumulation and plaque formation are central to AD pathogenesis.

Aβ accumulation and plaque formation are central ... In neurons, CD2AP is essential for dendritic spine formation and stability, while in microglia, excessive CD2AP activity may promote ...