Worldwide obesity rates have more than doubled since 1990, with nearly a billion people now falling into the category. Though ...

Friedman’s laboratory at the Rockefeller University cloned the leptin gene in 1994. “Before our research, the cause of obesity in diet-induced obese mice was unknown, leaving a critical gap in our ...

Since the discovery in 1994 of the obesity gene and its product, the fat-busting protein leptin, scientists have been racing to understand and apply this modern marvel. The ob gene -- ob for obesity - ...

In this study we investigated the physiological effects of elevated leptin in lean mice during discrete developmental time periods on subsequent body weight. Male and female mice that were exposed ...

Researchers say study findings have important implications for our understanding of the pathogenesis of obesity and potential therapeutic applications.

Leptin, a hormone primarily produced in the fat cells of the ... In this project, student researchers will work with laboratory mice, gaining hands-on experience in behavior studies. The student will ...

Clinical trials with r-Met-hu-leptin were also performed for the treatment of hypothalamic amenorrhea, where a 3-month administration resulted in the appearance of spontaneous menstrual cycles ...