Most obese patients grow resistant to satiety signals from the hormone leptin. A new study shows that leptin sensitivity can be restored in mice, leading to weight loss.

Researchers say study findings have important implications for our understanding of the pathogenesis of obesity and potential therapeutic applications.

Friedman’s laboratory at the Rockefeller University cloned the leptin gene in 1994. “Before our research, the cause of obesity in diet-induced obese mice was unknown, leaving a critical gap in our ...

As the researchers describe in a paper in Cell Metabolism, the drug rapamycin restores leptin sensitivity to diet-induced obese mice, leading to significant loss of fat with only minimal effects ...

Since the discovery in 1994 of the obesity gene and its product, the fat-busting protein leptin, scientists have been racing to understand and apply this modern marvel. The ob gene -- ob for obesity - ...

In this study we investigated the physiological effects of elevated leptin in lean mice during discrete developmental time periods on subsequent body weight. Male and female mice that were exposed ...

Using a mouse model of the disease, May-yun Wang et al. 1 tested the effects of treating diabetes with another hormone, leptin. Leptin is secreted by fat cells and is known for modulating energy ...

Hoth Therapeutics, Inc. (NASDAQ: HOTH), a clinical-stage biopharmaceutical company, today announced preclinical findings that highlight the potential of Glial Cell Line-Derived Neurotrophic Factor ...

Clinical trials with r-Met-hu-leptin were also performed for the treatment of hypothalamic amenorrhea, where a 3-month administration resulted in the appearance of spontaneous menstrual cycles ...

Leptin, a hormone primarily produced in the fat cells of the ... In this project, student researchers will work with laboratory mice, gaining hands-on experience in behavior studies. The student will ...