For a long time there was conflicting data on whether or not beta cell progenitor cells existed in the pancreas, he added; in particular, the expression of Neurogenin 3(Ngn3), the earliest islet beta ...

In this type of diabetes, the immune system specifically destroys insulin-secreting beta cells in the pancreatic ... Given the critical role that pancreatic islet cells play in type 2 diabetes ...

Last year, CellTrans claimed the first FDA approval for a cell therapy for type 1 diabetes, Lantidra (donislecel) consisting of insulin-producing islet beta cells taken from deceased donors.

As it has been established that a few islet antigen–specific T cells in a sea of nonspecific bystanders can drive complete beta-cell destruction ... mast cells and various dendritic cell subsets ...

which may facilitate the islet response to cholinergic activation. In addition, δ-cell SST is implicated in the nutrient-induced suppression of glucagon secretion. 1 Beta Cell Development and ...