an increased depth of intestinal crypts, an elevation of the mitotic and the labeling index of crypt cells, and a decrease in the ratio of height of the villi to depth of the crypts. Metabolically ...

Intestinal organoids allow researchers to investigate organ development and patient-specific disease pathology; however ... stem cells to self-organize into organoids with patterned crypt-like ...

Hirst Professor of Oncology in Pathology in the Department of Pathology ... initiation of colorectal cancer where damage to the intestinal crypts causes a decrease in aPKC protein expression ...