Because diabetes essentially results from the body's failure to respond to insulin, some researchers are trying to understand the signal transduction pathways that translate the binding of insulin to ...

Thus, neuronal insulin-like signaling appears to be a key regulator of various essential functions in C. elegans, and the metabolic and reproductive defects induced by whole-body deletion of DAF-2 ...

and the IGF-1 (insulin-like growth factor) receptor, which is essential for the survival of many tumor types. Signal transduction companies currently face two key challenges: First, the pathways ...

which can be programmed to differentiate into insulin-producing cells. Understanding the signal transduction pathways involved in the differentiation process is vital to the success of this approach.