News Medical on MSN3d
Adrenomedullin hormone as key driver of insulin resistance in obesity-linked type 2 diabetes
Researchers investigate the underlying mechanisms of endothelial insulin resistance involved in obesity-associated diabetes.
C&EN4d
If insulin can’t get into tissues, it can’t act
If insulin can’t get out of blood vessels, it can’t act in its target tissues. “Endothelial cells are full of insulin ...
News Medical on MSN8d
How olive oil bioactives regulate genes linked to insulin resistance
Olive oil bioactives, including MUFAs, polyphenols, and triterpenoids, modulate gene expression linked to insulin sensitivity ...
High levels of adrenomedullin found to promote obesity-associated insulin resistance
Adrenomedullin (ADM) inhibits endothelial insulin signaling, contributing to obesity-associated insulin resistance, according ...
Medscape14d
CD14 Modulates Inflammation-driven Insulin Resistance
One way to decrease CD14 signaling is to deliver rh-sCD14 that competes with endogenous CD14 receptor in the membrane ... and improved insulin action. This was found not only at the individual ...
Nature5y
The JNK diet
In this study, Karin and colleagues unveil two new mechanisms of action for JUN N-terminal kinase 1 (JNK1) in promoting obesity-induced insulin resistance. They show that JNK1 expression in non ...
GEN7d
Obesity-Linked Hormone Adrenomedullin Disrupts Insulin Signaling
Adrenomedullin disrupts insulin signaling in blood vessels, leading to systemic insulin resistance in obesity-associated type 2 diabetes.