Researchers investigate the underlying mechanisms of endothelial insulin resistance involved in obesity-associated diabetes.

If insulin can’t get out of blood vessels, it can’t act in its target tissues. “Endothelial cells are full of insulin ...

Preclinical trials using mice fed a high-fat diet (HFD) revealed additional benefits. HPH-15 not only improved insulin sensitivity but also lowered blood glucose levels from 11.1 mmol/L to 8.2 ...

Adrenomedullin (ADM) inhibits endothelial insulin signaling, contributing to obesity-associated insulin resistance, according ...

Olive oil bioactives, including MUFAs, polyphenols, and triterpenoids, modulate gene expression linked to insulin sensitivity ...

Announcing a new article publication for BIO Integration journal.   Diabetes, a common metabolic condition, poses a substantial health burden worldwide. To revolutionize diabetes management, enhance ...

One way to decrease CD14 signaling is to deliver rh-sCD14 that competes with endogenous CD14 receptor in the membrane ... and improved insulin action. This was found not only at the individual ...

In this study, Karin and colleagues unveil two new mechanisms of action for JUN N-terminal kinase 1 (JNK1) in promoting obesity-induced insulin resistance. They show that JNK1 expression in non ...

Adrenomedullin disrupts insulin signaling in blood vessels, leading to systemic insulin resistance in obesity-associated type 2 diabetes.

Tyrosine-protein phosphatase non-receptor type 1 (PTP1B) acts as a negative regulator of the insulin signaling pathway by dephosphorylating both the insulin receptor (IR) and the insulin receptor ...