Mapping the input-output function of the PHO5 promoter. ... The traces in Figure 2f were generated using the 'ode15' function in MATLAB from the model parameters. Promoter occupancy model.

Data were examined with pClamp 10 software (Molecular Devices) and thereafter analyzed with custom-written Matlab routines. Mean peak amplitudes, 10–90% rise times and decay time constants were ...

Many eukaryotic signaling proteins are regulated by a modular allosteric mechanism: a catalytic 'output' domain—which in isolation is constitutively active—is repressed by modular 'input ...

The Hill functions, H h (x) = x h / (1 + x h), have been widely used in biology for over a century but, with the exception of H 1, they have had no justification other than as a convenient fit to ...