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dipeptidyl peptidase (DPP)-4 inhibitors. Sitagliptin selectively inhibits the action of DPP-4, the primary enzyme degrading the incretin hormones, allowing glucagon-like peptide-1 and glucose ...

DPP4 Inhibitors Dipeptidyl peptidase-4 drugs help regulate blood sugar by preventing the breakdown of incretin hormones, which in turn increases insulin production in response to meals.

GLP-1-based therapy: incretin mimetics (GLP-1 analogues) and incretin enhancers (DPP-4 inhibitors) are now available for the treatment of Type 2 diabetes. Initial combination therapy with a DPP-4 ...

Saxagliptin, metformin HCl (ext-rel); 5mg/500mg, 5mg/1000mg, 2.5mg/1000mg; tabs. Saxagliptin is a competitive DPP4 inhibitor that slows the inactivation of the incretin hormones, thereby ...

Liraglutide, an acylated GLP1 analogue that requires daily dosing, is another incretin mimetic in Phase III trials. The chief advantage of small-molecule DPP4 inhibitors over injected GLP1 ...

Enrollment completed in Phase 2a CBeyond™ trial of CB1 inhibitor, nimacimab ... of action with attributes differentiated from incretins. We believe nimacimab’s product profile is well ...