IRF3 can then go to the nucleus to trigger transcription of inflammatory genes. This pathway plays a critical role in mediating immune defense against double-stranded DNA viruses. The innate immune ...

as a negative regulator of the type I interferon signaling pathway, and that SMYD3 directly catalyzes the dimethylation of IRF3 at lysine 39. Researchers first discovered that SMYD3 negatively ...

As they dissected the signaling cascade of the MAVS pathway, Chen’s interest naturally turned to ... the cytoplasm and applied it to a second set of cells, where they tracked IRF3 activation as a sign ...

More information: Zixuan Wang et al, Direct lysine dimethylation of IRF3 by the methyltransferase SMYD3 attenuates antiviral innate immunity, Proceedings of the National Academy of Sciences (2025 ...