This method results in transgenes that integrate into the genome of the cell. The flexibility of the expression of the genes is lost upon integration which is problematic once the reprogramming ...

Plath's team further discovered that the stages of reprogramming to iPSC are different from what was expected. They found that it is not simply the reversed sequence of stages of embryo development.

Because a TP53 hairpin RNA cassette is used in episomal reprogramming, there are concerns about genomic integration in the resulting hiPSC lines. In fact, the rate of aneuploidy with this method is ...

The iPSC Reprogramming mRNA-LNP Kit represents a cutting-edge platform designed to reprogram somatic cells into induced pluripotent stem cells (iPSCs) using non-integrative mRNA and lipid ...

Scientists find stem cell reprogramming technique is safer than previously thought Date: October 7, 2011 Source: Scripps Research Institute Summary: Stem cells made by reprogramming patients' own ...

Avoiding many of the pitfalls associated with conventional iPSC reprogramming methods that can introduce genetic instability, PSXi013 has been reprogrammed using our state-of-the-art, footprint-free ...

This new method of directly generating endothelial cells from fibroblasts has significant implications for generating patient-specific endothelial cells, especially for regenerative purposes. By ...