Two-thirds of patients with moderate or severe plaque psoriasis had complete or nearly complete clearance at 4 months with an ...

The IL-23/IL-23R signalling pathway plays a vital role in the pathogenesis of plaque psoriasis and other immune-mediated inflammatory diseases. JNJ-2113 selectively inhibits IL-23 signalling and ...

"With over a quarter century of innovation in inflammatory bowel disease, coupled with our deep expertise in the IL-23 pathway, we are excited about these results and the groundbreaking potential ...

IL-23 initiates and perpetuates both innate and ... Overall, these findings suggest that agents affecting LTB4 biosynthetic pathways may prove useful for primary or secondary prevention of heart ...

Spyre Therapeutics' innovative combination therapy approach targets multiple inflammatory pathways. Learn why SYRE stock is a Buy.

Tyrosine kinase 2 (TYK2), expressed in astrocytes and microglia, is involved in the activation of pathways triggered by proinflammatory cytokines, such as IL-23, IL-12 and type I interferons (IFNs), ...