Whereas early recombinant products approved were invariably replacement proteins, displaying amino acid sequences identical to the native human molecule (e.g., human insulin, Factor VIII ...

Since CRE sites can display high variability and remain active, those containing single base pair differences from human have been included. The chicken and zebrafish insulin promoters share so ...

So although we were no longer working on amino-acid sequencing, we had developed a more rapid method for doing it. The next sequence that we tackled was that of the 15,569 residues of the human ...