The use of high-dose methotrexate (HD-MTX) has improved survival rates. This article describes the experience of a patient treated with HD-MTX and outlines the essential aspects of care for the ...

Initially 12g/m 2 IV infusion over 4 hours; may be increased to 15g/m 2; see literature for leucovorin rescue dosing with high-dose methotrexate. Be fully familiar with this drug's toxicity before ...

Methotrexate (MTX) has been used for rheumatoid ... The appropriate route of administration and optimal dose should be individualized depending on the profile and response of the patient.

cilostazol (consider reduced dose), citalopram (limit dose to max 20mg/day), high-dose methotrexate (consider temporary withdrawal of PPI). Caution with drugs that may cause hypomagnesemia (eg ...

Discontinuing tyrosine kinase inhibitor maintenance after extended complete molecular response should only be attempted as part of a clinical trial, the researchers say.