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Stem cells can tailor their role in gene therapy based on the underlying disease, study suggests
Hematopoietic stem cell gene therapy (HSC-GT ... By tracking vector integration sites as unique markers of clonal identity, the team assessed how transplanted HSCs contributed to blood cell ...
Medscape22d
Hepatic Stem Cells and Liver Repopulation
express hematopoietic stem cell markers (c-kit, CD34) and early hepatocytic markers (AFP, albumin, and CK14). Upon removal of the feeder layer, the cells begin to express mature hepatocytic ...
EurekAlert!5d
Right on schedule: mimicking developmental signal timing improves in vitro blood progenitor differentiation
This study fills a crucial gap in our understanding of blood cell formation from human pluripotent stem cells (hPSCs). Genome-wide comparisons of hPSC-derived blood progenitor cells with in vivo blood ...
Nature1y
Purified hematopoietic stem cells can differentiate into hepatocytes in vivo
HSC-derived hepatocytes expressed the same hepatocyte markers as bone marrow-derived ... Weissman, I.L. Translating stem and progenitor cell biology to the clinic: barriers and opportunities ...
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Research Unlocks Secrets of Stem Cell Retention in Bone Marrow
Stem-cell transplants treat diseases in which an individual's hematopoietic (blood-forming ... while those without the markers readily exited the marrow when drugs for boosting HSCs mobilization ...
The Scientist2y
Hematopoietic Stem Cells and Their Role in Development and Disease Therapy
Jen has a PhD in human genetics from the University of California, Los Angeles where she is currently a project scientist. She enjoys teaching and communicating complex scientific concepts to a wide ...
CRISPR screen identifies EIF3D as critical regulator of stem cell pluripotency maintenance
A team of CiRA researchers has uncovered the crucial role of EIF3D—a protein translational regulator—in primed pluripotency.
Stem cell infusion timing can prevent acute graft-versus-host disease
A research team has identified the impact of stem cell infusion timing on the incidence and severity of acute ...
Neural stem cells outside the brain: Discovery opens new paths for regenerative medicine
For decades, scientists assumed that neural stem cells (NSCs) only occur in the brain and spinal cord. A new international ...
Phys.org12d
Drug-delivering aptamers target leukemia stem cells for a one-two knockout punch
Though they make up a tiny fraction of cancerous cells, leukemia stem cells have the ability to evade chemotherapy by ...
Nature1y
Use of the green fluorescent protein as a marker to identify and track genetically modified hematopoietic cells
The GFP marker significantly enhances the ability ... marking protocols designed to optimize gene transfer into hematopoietic stem cells. Flow cytometric purification of GFP-expressing bone ...
Medscape3mon
Topics in Pediatric Leukemia -- Hematopoietic Stem Cell Transplantation
Hematopoietic stem cell transplantation (HSCT) plays a significant therapeutic role in treating these patients. Theodore B. Moore, MD, Director, UCLA Pediatric Bone Marrow Transplant Program ...