Figure 3: A basic schematic of the Hedgehog (HH) signalling pathway ... compared with DNA extracted from a control group without skin cancer 70. However, the overlap between individuals in ...

We have also conducted an immunohistochemical study for expression of PTCH1 and SMO in a large panel of normal, ductal carcinomas in situ (DCIS), and invasive breast cancer (IBC ... these data suggest ...

Several components of the hedgehog (Hh) pathway are crucial to ... The requirement for canonical Wnt/β-catenin signaling in Hh-driven BCC development is increasingly recognized.

A phase II trial found that T-VEC improved tumor resectability in 50% of patients ... Neoadjuvant therapy with hedgehog inhibitors has an overall response rate (ORR) of 71%, but adverse events ...