The Hedgehog (Hh) pathway plays central roles in animal development and stem-cell function. Defects in Hh signalling lead to birth defects and cancer in humans. The first and often genetically ...

Molecular characterization & regulation of cancer stem-like cells CSCs may reside in unique tumor niches and utilize normal stem cell regulation pathways (e.g., Wnt, Notch and hedgehog).

Hedgehog, and Hippo-YAP, which regulate stem-like properties in cancer cells. By influencing these pathways, ubiquitination emerges as a potentially powerful therapeutic target to disrupt the ...

An alternative option is to use other cell types, such as human embryonic stem cells ... expression of components of the hedgehog signal transduction pathway, which is essential for terminal ...