Part of the HBV polymerase gene flanking the YMDD motif ... M552I was detected before therapy in one patient but M552V became the domain strain after therapy. Until 52 weeks of therapy, serum ...

but selection of HBV polymerase mutants with enhanced replication by lamivudine treatment has also been reported. [19] In the present study, the mean values of HBV DNA levels of the five patients ...